I did several Liver Flushes before I did ANY other flushes and I did just fine. So, go ahead. You will be ok. Flush away!
The orthinine absorbs the toxins your body will be releasing, which could keep you awake. But, there again, I have done several flushes without orthinine. But, since this is your first flush, you will be very nervous about everything, so you make the decision about taking the sedative tonight.