"Niacin" is the wrong form of the substance he should take. It's "niacinamide", or even better, "Nicotinamide adenine dinucleotide" (NAD). This in combination with Vitamin C, B6, etc, usually in mega-dose amounts (2000mg+)
Rather than experimenting on your own, especially because of the severity, I suggest you try to get him to an ORTHOMOLECULAR psychiatrist, or at least read up on Dr. Abram Hoffer's work and protocol.