Arsenic and Cadmium

>> The kidney damage inflicted by cadmium poisoning is irreversible

Nothing is irreversible, the issue is that cadmium usually has a friend called mercury and both need to be removed. This of course can't happen when our educated quacks consider mercury good for you...

from:
http://www.dmsa-chelation.info/


Arsenic and Cadmium
Environmental arsenic and cadmium exposure comes from pollutants discharged from industries utilizing these metals, including herbicide and battery manufacturers. These metals are also found in cigarette smoke.

Cadmium, as well as lead and mercury, can interact metabolically with nutritionally essential metals. Cadmium interacts with calcium in the skeletal system to produce osteodystrophies, and competes with zinc for binding sites on metallothionein, which is important in the storage and transport of zinc during development.

Biliary excretion seems to be an essential factor for the fecal elimination of cadmium and arsenic, although these metals may be also excreted in the urine.

How DMSA works
In healthy individuals, approximately 20 percent of an oral dose of DMSA is absorbed from the gastrointestinal tract. Ninety-five percent of the DMSA that makes it to the bloodstream is bound to albumin. One of the sulfhydryls in DMSA binds to a cysteine residue on albumin, leaving the other S-H available to chelate metals. In healthy fasting men, 90 percent of the DMSA recovered in the urine was found to be mixed disulfides (where DMSA is attached to one or two cysteine molecules), and 10 percent was free unchanged DMSA. No mixed disulfides were found in the blood. It is thought these disulfides are formed as albumin releases DMSA in the kidneys.

There is no question that DMSA is more readily absorbed when it is taken on an empty stomach. However, some people experience gastric upset when they take DMSA apart from food, and that is more likely to occur in children. Therefore, caution and flexibility are required in regard to this.
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