Put it directly on the toenail daily.My mother had a bed of fungus under the two big toes.She said it came with old age.I laughed.I started treating her about two months ago,and the fungus is almost gone now.Another friend of mine also had the problem,started treating,and the nail fell off.The fungus is gone now,and the nail is growing back.It will work.Soaking in hot salt water before treatment will speed up the process.Also,a little real pine oil could benifit.Steven West