I don't know about the crankiness and what you mentioned, but just a warning....I was taking a lot of Betaine and my throat started getting scratchy and my voice was hoarse. Then I couldn't speak! It turns out that Betaine is made from Beets and high amounts of beets can temporary disable your vocal chords. It doesn't do any long term damage, but it can freak you out! That's why, just a warning. Now I just take one per meal.