The Master-Cleanse can be used as a starting point but you must make permanent changes for permanent weight loss. I kept weight off for a while - it has always depended on how consistent I was with my diet after wards. I might lose 14lbs, then gain 3 back right away and keep 10ish pounds off for a while. So yeah with changes in diet, you can. I never went all the way back up to the weight I was before starting cleansing because my diet is better. After this MC, I'm going to use Paul McKenna's method to change my bad habits so I can be more consistent b/c I feel better when I eat better. Good luck! :-)