Some women have no issues at all and your wife may be one of them. I don't know any way to tell who the lucky ones are. I am extremely healthy and fit, 43 years old. I had mine for 3 months, and I felt absolutely awful the entire time. It has been out for a month this week and I am still not back to normal. The low back pain, acne, fatigue and nausea are still with me, although it is getting better little by little. My doctor said side effects should stop immediately - well they didn't!