Re: Hello, I'm new and I really would like to make a friend or two.

Hi ATA,

Here's another website:
http://rarediseases.info.nih.gov/GARD/QnA.aspx?PageID=4&CaseID=20839&DiseaseI...


In case you can't read it in this message, just go to
http://rarediseases.info.nih.gov

Then click on Rare Diseases and Related Terms under Rare Diseases Information. Look for Trimethylaminuria, and see Questions & Answers. Click on the 2nd question, "I think I may have trimethylaminuria. I would like more information that could be shared with my doctor that could help my doctor in diagnosing the condition." and then on "What treatment is available for trimethylaminuria?" and "Can trimethylaminuria be cured by replacing FMO3, the enzyme, which when absent, is believed to cause the condition?" Here are excerpts from this:

What treatment is available for trimethylaminuria?

Although there is no cure for trimethylaminuria, it is possible for people with this condition to live normal, healthy lives. The following are some ways a person with trimethylaminuria can reduce symptoms of odor [3]:



Avoiding foods containing trimethylamine and its precursors (choline and trimethylamine-oxide). Trimethylamine is present in high levels in milk obtained from wheat-fed cows. Choline is present in high amounts in: eggs; liver; kidney; peas; beans; peanuts; soy products; brassicas (brussel sprouts, broccoli, cabbage, and cauliflower); and lecithin and lecithin-containing fish oil supplements. Trimethylamine N-oxide is present in seafood (fish, cephalopods, crustaceans). Freshwater fish have lower levels of trimethylamine N-oxide.
Taking low doses of Antibiotics to reduce the amount of bacteria in the gut. This suppresses the production of trimethylamine.

Taking laxatives can decrease intestinal transit time and reduce the amount of trimethylamine produced in the gut.

Taking supplements to decrease the concentration of free trimethylamine in the urine.

Activated charcoal taken at a dose of 750mg twice daily for ten days.

Copper chlorophyllin taken at a dose of 60mg three times a day after meals for three weeks.

Using soaps with a moderate pH, between 5.5 and 6.5. Trimethylamine is a strong base (pH 9.8), thus soaps with pH closer to that of normal skin help retain the secreted trimethylamine in a less volatile form that can be removed by washing.

Taking riboflavin (vitamin B2) supplements to enhance any residual FMO3 enzyme activity. Recommended intake is 30-40mg taken 3-5 times per day with food.

Avoiding factors that promote sweating, such as exercise, stress, and emotional upsets.
NOTE: Individuals should follow the treatment advice of their health care provider and should not attempt to self-administer these treatment approaches. Medications and supplements can have unintended interactions, and dietary restrictions can result in nutritional deficits.
Choline is essential for nerve and brain development in fetuses and infants, therefore, pregnant and breast-feeding women should consult with their health care provider before restricting their dietary choline.

People with trimethylaminuria may also find the following to be helpful:



Behavioral counseling to help with Depression and other psychological symptoms.

Genetic counseling to better understand how they developed the condition and to be aware of the risks of passing this disease on to the next generation. Visit the Services section to find a list of online resources that can assist you in finding a genetics clinic near you.


Last Reviewed: 12/7/2007

Can trimethylaminuria be cured by replacing FMO3, the enzyme, which when absent, is believed to cause the condition?

Unfortunately at this time, enzyme replacement therapy is not an option in the management of trimethylaminuria.

Last Reviewed: 12/6/2007

Hope this helps.
mpdela