I think I can safely say that 40k-100k HU Cayenne aids with difficult to reach critters including Heartworms and Schistosoma blood flukes (usually in the mesenteric artery).
Start slowly with 40k and work your way up, the real issue isn't that it doesn't work but that it may create too many biotoxins and make you feel worse. Specifically the death of Schistosoma where the blood supply is close to the kidneys may cause trouble…
Besides Colloidal Silver this is the cheapest most effective item I have stumbled on.
NOTE: This is for difficult parasites and NOT a substitute for a normal flush
NOTE2: Results are from 4 users, those using 100k Cool Cayenne had better results vs. the 40k Cool Cayenne