Yeah, I'm no expert, but I try to do what seems/feels best. I've been taking enzymes with meals and saving the probiotics to take with my evening dose of Miracle-Mineral-Supplement (before bed). Also, I think the Miracle-Mineral-Supplement instructions say not to take Miracle-Mineral-Supplement with vitamin C. So I take my daily A-Z vitamin (which has C in it) with dinner between 5 and 6 pm. My nighttime MMS dose comes around 10 pm, so I'm hoping that's far enough away from the vit C.