Yes, I do take Rhodiola every day, and yes I have had short breaks when I have gone away for a few days and forgot to take it with me. Depending on how long you have been taking it, I find that I can go 3 to 4 days without a backslide but any longer than that will let you start feeling the way you don't want to feel. Now I feel I should say that when I resume using it it takes a few days to get back to peak. It can take different amounts of time on various people to reach its full potential. As for your other question about becoming immune to it.......well it has been three years with no less effect?????