I have noticed it's getting better. But when I take a drop of lugol's every other day it get's worse. So I'm going to lay off the lugols till done with parasite cleanse. It possibly is a good sign (the pain)I read a post on iodine clinic that said that's what happened to her at first then her cysts got much better. But I think the combination of humaworm and even the small dose of iodine is too much for me.