It would be a surrogate for something that you crave but cannot and don't know how to find.
And taking surrogates always leads to addiction. Soon, you'd forget all about love, and would crave more and more one night stands, until you hit rock bottom and feel like a whore. Then, to ease the pain, other surrogates would come in: perhaps alcohol, or drugs, or at least sweets and TV... and you'd be feeling much worse then now.
That'd be one way of looking at it.
Another way is this: do you think that just phyisical sexual pleasure, with no interest in the other person, would be enough? If so, then why not masturbate? Oh, because there is no other person, right?
Well then, we are coming to sqaure one: you actually don't crave physical sexual stimulation, you crave a meaningful sexual relationship with another human being and not just a one night stand.
Any way you look at it, it's best to resolve the issue at hand: how to find, meet and love another person and be loved in return.
Since I believe that we are all born to learn a thing or two about love, as "love is the answer", that seems to be the best path for you and all of us, and also the healthiest.
Don't expect quick results, and try not to look at relationship as a "success" or "failure". Relationships just happen and they help us get to know ourselves.
As for not being liked by those you like: we are naturally built to like people that like us. There is a lot of unnoticable and unseen communication going on between people when they first meet. Those signs tell our subconscious mind whether we have a chance at all or not (with another person). Why you are using those signs against yourself is the real question. It is not a matter of them not liking you; it is a matter of you liking people who you know won't care for you.
This usually starts with upbringing... start digging there if you want to find gold