Great topic doc ! healing leaky gut...

Totally agree diet is first and probably the foundation of healing protocol.

Regarding supplements - i believe its a question of type of infections, state of GI and timing. It's obvious that not everything works for everybody.
That's why I think your advice with test first might bring valuable information. That plus doctor/practititoner experience and acces to information could be great asset in your recovery endevour.

Examples:all of these were recommended to me for LGS like doctors recommend pills but were NOK:
- broth proved to be absolutely great for "solving" leaky gut - but not the fat one or containing too much gelatine - so light version :) was OK. in some cases like viruses or some protozoa the fat and gelatine one could be problematic.
- glutamine, slippery elm... i've had bad reactions and worsten the symptoms - did not know why neither my practitioner (lack of access to information). i've read somewhere (cant remember where due to AF sorry :) that glutamine NOK for some bacterial infections or even candida. cause they can feed on it plus if pancreatic insufficiency is present broth is not properly digested so more problem...
- probiotics the same - great help when you know what infection or intolerance do one have so be able to avoid diary one if the case.
- Colostrum - same story

so i guess knowing as much as possible about type of infections (characteristics of pathogens) tolerance state of GI etc could help to better target or prioritize the protocol for leaky gut.
I remember you previously said not two patient are alike :) i believe its true also here

I've gone as far as I can go with diet. It's working to some extent, but 23 years is long time to wait. It looks like I either am celiac or extremely gluten sensitive. Since I went off gluten way back when I've been detoxing my small intestine ever since.

Last time I tried colostrum I started to get some pretty severe gut pain- still trying to track down what exactly is the root of the pain. I will try NAD again, I think it was in some pills I took a long time ago. I got the same gut pain with raw turmeric, strict vegetarian diet and also triphala.

Been doing probiotics and fermented foods for a long time, it helps speed up detox but doesn't seem to get me closer to feeling good.

Enzymes, I've tried pancreatin, hcl acid, and I used to take some vegetarian multi enzymes. Nothing seems to impact the lieaky gut much. Too much of the hcl burns on the way out. Pancreatin is good for chewing up the small intestine waste, but that stuff is already coming out of me anyway.

I can't say for sure that I have leaky gut but my gall bladder/liver problems are not being fixed by flushes so leaky gut is one of the suspects.