Long term aspirin usage prevents cancer Long term aspirin usage prevents cancer
Long term aspirin usage prevents can... 
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The summary is that the long-term benefits of daily aspirin use prevents cancer.
http://ca.news.yahoo.com/aspirins-anti-cancer-effects-backed-more-research-22...
Aspirin's anti-cancer effects backed by more research
CBC
– 2 hours 34 minutes ago
Newly published international papers are adding to growing research that Aspirin, commonly used now for people in danger of heart attack and stroke, may also help prevent and treat cancer.
Two papers in the Lancet and one paper in the Lancet Oncology, all published Tuesday, chronicle research suggesting daily use of acetylsalicylic acid (ASA, sold under the brand name Aspirin in Canada and other countries) can reduce the long-term risk of cancer death.
However, researchers from the U.K. and Italy, led by Prof. Peter Rothwell of the University of Oxford and John Radcliffe Hospital in England, stress that the short-term effects of daily use of the non-steroidal anti-inflammatory, as well as how risky or beneficial it may be over time, have yet to be determined.
Currently, in North America, medical practitioners are urged to put anyone who has had a heart attack or stroke on anti-platelet therapy (low-dose ASA, to prevent clots) because it can greatly reduce the risk of deadly recurrence.
The Lancet-published papers break down like this:
Article 1: The authors studied individual patient data from 51 randomized trials of daily Aspirin versus no Aspirin use to prevent heart attacks. They found Aspirin reduced the risk of a cancer death by 15 per cent compared with control subjects, and this improved to a 37 per cent reduced risk of a cancer death for patients taking the medication five years and longer. The reduction in cancer deaths for those taking Aspirin resulted in a 12 per cent reduction in deaths not related to the cardiovascular system. "In view of the very low rates of vascular events in recent and ongoing trials of Aspirin in primary prevention, prevention of cancer could become the main justification for Aspirin use in this setting," the researcher wrote.
Article 2: For the study on the effect of Aspirin on how cancer spreads (metastasis), new data was collected on metastases of cancers that were diagnosed during all five large randomized trials of daily Aspirin (75 milligrams or more daily), versus control for the prevention of cardio-related events in the U.K. They found that, with an average followup of 6.5 years, the use of Aspirin reduced the risk of cancer with "distant metastasis" by 36 per cent, cut the risk of colon, lung and prostate cancers by 46 per cent, and reduced the chance of bladder and kidney cancers by 18 per cent. Aspirin reduced the overall risk of fatal cancers in the trial populations by 35 per cent, but not the risk of blood and other fatal cancers. "These findings provide the first proof in humans that Aspirin prevents distant cancer metastasis," the researchers note, adding that metastasis had been prevented in previous studies involving animals.
Article 3: This paper reviewed the effect of Aspirin on metastatic cancer using a review of observational versus randomized trials. Researchers found observational studies showed a 38 per cent reduced risk of colorectal cancer, compared to 42 per cent in randomized trials. Similar matches in risk were found for esophageal, gastric, biliary and breast cancer, prompting the researchers to say, "Observational studies show that regular use of Aspirin reduces the long-term risk of several cancers and the risk of distant metastasis."
In a commentary linked to the published research, scientists from Brigham and Women's Hospital, Harvard Medical School, in Boston said the studies make "a convincing case" that the cardiovascular-protection and anti-cancer benefits of Aspirin outweigh the harms that may include excess bleeding (hemorrhage), and "moves us another step closer to broadening recommendations for Aspirin use."
However, they warn, "these analyses do not account for less serious adverse effects on quality of life, such as less severe bleeding."
Although the Lancet-published studies received no specific funding, Rothwell has received honoraria for serving on advisory boards, clinical trial committees and giving talks from some pharmaceutical companies with an interest in anti-platelet agents, including Bayer, AstraZeneca, Boehringer Ingelheim, Sanofi-BMS and Servier.
"Although the Lancet-published studies received no specific funding, Rothwell has received honoraria for serving on advisory boards, clinical trial committees and giving talks from some pharmaceutical companies with an interest in anti-platelet agents, including Bayer, AstraZeneca, Boehringer Ingelheim, Sanofi-BMS and Servier."
That pretty much says it all. If not, Google "aspirin dangers". And then check and see how many of the aspirins used in studies which showed benefits for reduced risk of stroke and/or heart attack were buffered with magnesium. All of the early studies which showed benefit used aspirin with magnesium and I suspect we may see some of the same effects for the anti-cancer aspirin products.
At any rate, changing to a healthy diet and lifestyle and building and keeping a strong immune system is the ticket for preventing cancer, not taking drugs. No one gets cancer or becomes ill due to a deficiency in aspirin or any other pharmaceutical item. A great many do become ill from taking unnatural pharmaceutical products.
"That pretty much says it all. If not, Google "aspirin dangers". And then check and see how many of the aspirins used in studies which showed benefits for reduced risk of stroke and/or heart attack were buffered with magnesium. All of the early studies which showed benefit used aspirin with magnesium and I suspect we may see some of the same effects for the anti-cancer aspirin products."
That's a silly back door approach to an alien conspiracy theory that has no validity whatsoever. I take an aspirin each day and I haven't seen a buffered product on the shelf in years. In fact, it's difficult to even find "Bayer" on the shelf any more particularly when Costco competes with them so well.
Those studies ALL include people in them who are on a healthy diet and lifestyle and preaching your line has never succeeded. (In fact, Michelle Obama gets trashed every day for promoting that same idea.) So, at the cost of aspirin these days I figure it costs me a good $3 a year to follow those guidelines and there are many other benefits to it besides cancer prevention - which is not why I take it. My goodness - Costco's bottom line (oh how I love those bottom lines) is going to really benefit from my $5 purchase every eighteen months.
From the original post:
"Aspirin reduced the risk of a cancer death by 15 per cent compared with control subjects, and this improved to a 37 per cent reduced risk of a cancer death for patients taking the medication five years and longer."
What is it about the 37% reduced risk of cancer deaths is it that you don't like?
Having spent a career in Information Technology it was commonplace to run into the Not Invented Here syndrome over and over again - at a horrible added cost to my employer.
NIH = Bruised ego.
http://en.wikipedia.org/wiki/Not_Invented_Here
Not invented here
Not invented here (NIH) is a term used to describe persistent social, corporate, or institutional culture that avoids using or buying already existing products, research, standards, or knowledge because of their external origins. It is normally used in a pejorative sense, and may be considered an anti-pattern. The reasons for not wanting to use the work of others are varied but can include fear through lack of understanding, an unwillingness to value the work of others, or forming part of a wider "turf war". The opposite culture is sometimes denoted proudly found elsewhere (PFE) or invented here.
As a social phenomenon, "Not Invented Here" syndrome is manifested as an unwillingness to adopt an idea or product because it originates from another culture, a form of nationalism.
An argument for NIH is to guard against an aggressive action by another company buying up a technology supplier so as to create a captive market. This may also guard against future supply issues due to political unrest or other issues.
In programming, it is also common to refer to the NIH Syndrome as the tendency towards reinventing the wheel (reimplementing something that is already available) based on the belief that in-house developments are inherently better suited, more secure or more controlled than existing implementations.
"What is it about the 37% reduced risk of cancer deaths is it that you don't like? "
Achieving it through the use of aspirin is what.
If you choose to take aspirin regularly and erode the lining of your stomach, increase the risk of intestinal bleeding and bleeding from the brain, feel free.
In addition, aspirin (acetylsalicylic acid) belongs to a family of allergens known as salicylates. People who are allergic are at risk of suffering serious side effects, including fatal ones. As a matter of fact, aspirin and aspirin related products kill over 30,000 people each year in the U.S.
As I said earlier, good nutrition and lifestyle and building and keeping a strong immune system it the best way to prevent cancer. People who do that can reduce their risks of cancer and other illness by much more than 37%. If you want to live and eat really healthily and throw in a few natural cancer preventives I believe that cancer is as much as 90% or more preventable.
Rather than being a nutrient, aspirin is an anti-nutrient. It depletes the body of the life-saving nutrient folic acid (as well as iron, potassium, sodium, and vitamin C). Symptoms of folic acid depletion include anemia, birth defects, elevated homocysteine (itself a significant risk factor for heart disease), headache, fatigue, hair loss, insomnia, diarrhea, and increased infection.
There may not be a huge amount of profit per bottle of aspirin sold, but with annual worldwide sales of over a billion dollars, it is huge moneymaker nevertheless. And Bayer continues to lead the market with sales actually increasing each year. Last year they increased 24%. Whatever profit there is, not a nickel of it will come from me.
"As a matter of fact, aspirin and aspirin related products kill over 30,000 people each year in the U.S."
Please back that up. The OP shows that dosages as low as 75 mg per day prevent cancer. Show us where that dosage kills people. Also show that the "natural" alternative, willow bark, is any better and that's been used for thousands of years. Yes there are people who are allergic to anything. I actually witnessed a guy go into convulsions after one Pabst Blue Ribbon beer. The medical diagnosis was that he was allergic to beer and could never again drink it. It happens all the time with a wide variety of food products.
Enteric coated tablets greatly reduce or even eliminate the stomach lining problems you cite and their cost is little more than the standard baby aspirin.
http://ezinearticles.com/?How-Many-People-Die-From-Cancer-Each-Year?&id=2...
...The total for every cancer death except nonmelanoma skin cancer in the United States is over 565,000 people. Lung cancer is first among the killer cancers in the United States. The unreported fact is that the invisible gas radon accounts for 21,000 lung cancer deaths each year for the United States.
By your logic exercise should be avoided as well. Jim Fixx "the
'father' of running" died while jogging. Not only him but many, many
others as well. Don't want to die? Don't jog. However, life
will eventually catch up with you and everyone else and your body will in fact
die.
"As I said earlier, good nutrition and lifestyle and building and keeping a strong immune system it the best way to prevent cancer."
As I said before, that's exactly what Michelle Obama teaches and how many follow it? In fact there are millions of Americans who hate her for the reason of that very specific recommendation.
Because white willow bark is much more expensive than aspirin
http://www.amazon.com/Natures-Way-White-Willow-Capsules/dp/B0001VWBGE/ref=sr_...
and in most cases only available at much higher mg than baby aspirin
http://www.amazon.com/Kirkland-Signature-Dose-Aspirin-bottles/dp/B002RL8FKW/r...
which is the amount shown in many of the studies that were cited.
Why can't "logical" individuals accept the fact that
http://www.bbc.co.uk/news/health-17443454
.....Taking a low (75-300mg) daily dose of the drug appeared to cut the total number of cancer cases by about a quarter after only three years - there were nine cancer cases per 1,000 each year in the aspirin-taking group, compared with 12 per 1,000 for those taking dummy pills.
.....And if patients stayed on aspirin for longer, their cancer death risk went down even further - by 37% after five years.
Aspirin is simply a manufactured element of willow bark. It's not that the link above is promoting aspirin and wild living as a way to prevent cancer, in fact in the study review a doctor says:
...for most fit and healthy people, the most important things they can do to reduce their lifetime cancer risk is to give up smoking, take exercise and have a healthy diet.
Are you aware Chris that the most difficult advice for a lung or throat cancer patient to follow is to - quit smoking? Even after lung removal? Just looking around us both in the USA and UK, how far does the advice of "...exercise and have a healthy diet go?" It ain't working! That's what Michelle Obama promotes here in the USA and millions of people hate her for it.
"Aspirin is simply a manufactured element of willow bark."
Aspirin is a synthesized version of the compound identified in willow bark as the primary active ingredient. It i no way comes from actual willow bark and, like all sythetics, is not the same as the natural version.
I am not sure that millions hate Michelle Obama for her advice on diet and exercise, but I can tell you why so many are unwilling to follow such advice or advice to quit smoking - because maim-stream medicine has spent billions and billions promoting the idea of obtaining a "cure in a bottle", and though patently wrong, it is far easier to take a maim-stream drug - such as aspirin - and continue with bad health habits than it is to make the effort to live and eat healthily.
