Xylitol and Cancer 
Koyae
13 y
14,432
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So, we have on RXlist and WebMD (which are syndicated together) and then echoed again on livestrong that oral xylitol taken daily in amounts > 50g causes tumor-growth, and therefore should be limited to some portion less than this.
Could that be entirely B-12 (which xylitol can inhibit I think) related or what?
I've already been through the literature a fair bit and have found nothing to indicate carcinogency of xylitol, infact quite the opposite with regard to mouth-sores and even hepatoma. All longterm studies I've viewed indicate that heroic "zill" (as I sometimes call it) gets the all-clear. Even a multi-generation rat study revealed nothing but "cosmetic" signs ( medline/7271602 ).
Another one I saw that did some extreme dosing both 10% and 20% showed what I have in my notes as "raised bone-density (higher serum Ca and alkaline phosphatase activity, lower levels of serum tartrate-resistant acid phosphatase versus control)." But let's be reasonable -- no one is going to eat that much even if it becomes the exclusive sweetener in this household after acclimation.
I've e-mailed WebMD about where they got their information and am waiting to hear back.
I figure to really put things in perspective if you consumed 50g white table Sugar for 3 years you'd also end up pretty ugly, but I'm thinking there's more to it.
SO -- is this just a foul rumor, or can anyone confirm?
- Re: Xylitol and Cancer saywhydoi
12 y
9,875
This is a reply to # 1,859,473I've recently read the WebMD claim about tumor risk too and was wondering what the sources were since I haven't been able to locate further information about this yet.
Did webMD get back to you with the original source?
Does anyone else know more about the possibility of a tumor concern with xylitol? - Re: Xylitol and Cancer FocusOnHealth
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Hulda Clark cleanses
Wormwood, Clove, Clarkia, Turmeric, Epsom Salt, Uva Ursi, Goldenrod
> So, we have on RXlist and WebMD (which are syndicated together) and then echoed again on livestrong that oral xylitol taken daily in amounts 50g causes tumor-growth, and therefore should be limited to some portion less than this.
Using key words like "xylitol", "tumor", "cancer", and/ or "carcinogenic", after a thorough search for scientific articles in the government's PubMed database (http://www.ncbi.nlm.nih.gov/pubmed) from 1964 through the Present, I've found nothing that would make me concerned about adding Xylitol to the food I eat.
I suspect there are, and always there will be web sites that make unsubstantiated claims without any references.
Perhaps because there is a conflict of interest. Perhaps their (usually unnamed) authors work in the Sugar industry. Or perhaps because they're MDs and/or oncologists whose best interest is to spread foul rumors, or engage in fear-mongering, or encourage the use of ordinary table sugar, or discourage the use of xylitol -- a truly wonderful substance with anti-tumor properties!
I repeat: With anti-tumor properties!
To prevent cancer, for starters, we need to say 'no' to MDs and oncologists http://aptarticle.com/health/how-10045-prevent-your-breast-cancer.html
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- Re: Xylitol and Cancer saywhydoi
12 y
9,753
MoreThis is a reply to # 1,982,822Thanks for posting this FocusOnHealth!
The thought that such unreferenced claims may be written by people in the Sugar industry did cross my mind too.
- Re: Xylitol and Cancer saywhydoi
12 y
9,753
- Re: Xylitol and Cancer saywhydoi
12 y
9,865
This is a reply to # 1,859,473Hi everyone,
I have been on the case: I've written to WebMD, received a kind reply from them and found the original sources behind their xylitol-tumor-link statement.
Their source was the Natural Medicines Comprehensive Database. So I emailed them too, to ask them about this particular xylitol issue and they very helpfully sent me this (quoted below), which I hope they'll be happy with me sharing to help anyone else who is concerned about the xylitol-tumor statement:
[QUOTE]
The wording from the SAFETY section of the Professional monograph says the following:
"POSSIBLY UNSAFE ...when used orally in very high doses, long-term. There is some concern that very high doses for extended periods of use can induce tumor growth (6815,6820). However, this effect has not yet been demonstrated in humans."
Here are the references used in those statements so that you can look into this further:
6815: Lee B, Sue D. Xylitol for prevention of dental caries. DICP 1989;23:691-2.
6820: Crapo PA. Use of alternative sweeteners in diabetic diet. Diabetes Care 1988;11:174-82.
[/QUOTE]
I have yet to find the articles and read them before saying any more on this topic, but I did find it a little reassuring that "this effect has not yet been demonstrated in humans".
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- Re: Xylitol and Cancer FocusOnHealth
12 y
9,902
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Hulda Clark cleanses
Wormwood, Clove, Clarkia, Turmeric, Epsom Salt, Uva Ursi, Goldenrod
Saywhydoi, THANKS for posting those two articles!
Hi Everyone, Finding the first one has been a challenge for me. (If it's not a challenge for you, please find it online, or in a medical library. And review it, if you can. If you can't review it, then just give me a link, or get me the document, and I will review it.)
However, I've been able to locate the second one. My evaluation/assessment of the second one is as follows:
In 1988 a registered dietician (RD), Phillis Crapo, wrote scholarly review of many-many articles titled, "Use of alternative sweeteners in diabetic diet". In her review she made the following statement (that WebMD probably refers to):
QUOTE: However, chronic intake of xylitol in animals has been shown to be associated with tumor induction and other pathology. END OF QUOTE.
However, she didn't support her statement by any evidence. Therefore her statement is just an unsubstantiated, questionable opinion that has little or no value.
In other words, in the first paragraph on page 177 (where she talked about tumors and xylitol) she should've referred to one of the referenced articles. But no, she failed to do so.
Additionally -- unless "chronic", "animals", "other pathology" and the rate and duration of feeding are defined -- her statement is also pretty vague.
Therefore, this text, the text that WebMD refers to, is just a vague, non-specific, questionable opinion NOT supported by any evidence.
Judge it for yourself. Her article can be found at http://care.diabetesjournals.org/content/11/2/174.full.pdf
I hope this helps.
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- Re: Xylitol and Cancer FocusOnHealth
12 y
10,069
This is a reply to # 1,988,697This one may be relevant as well. As to xylitol, tumors, animals and lab experiments there are many other articles on xylitol vs. table sugar.
One example is "Junko Sato,2 Yeu-Ming Wang, and Jan van Eys Department of Pediatrics, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030". In it lab rats with various pre-existing liver tumors received a 10% IV solution of Xylitol at the rate of 2 g per kg body weight. The researchers found the hepatocellular carcinoma was markedly deficient in the ability to synthesize acid-insoluble glycogen and glycoprotein from xylitol.
Translation: researchers found that (on pre-existing tumors) the xylitol caused significantly less harm than ordinary table sugar. Note the tumors were pre-existing ones. No, they were not caused by xylitol.
The full text of the article can be found at http://cancerres.aacrjournals.org/content/41/8/3192.full.pdf
- Re: Xylitol and Cancer saywhydoi
12 y
9,742
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Hulda Clark cleanses
Wormwood, Clove, Clarkia, Turmeric, Epsom Salt, Uva Ursi, Goldenrod
Hi FocusOnHealth,
I too have read the 1988 Crapo article now and came to the same conclusions you arrived at. I was quite surprised that such a bold statement had no references! Thanks for your clear run-through your critique :)
Still haven't been able to get my hands on the other Lee & Sue (1989) article.
It does seem likely however that if there was some real risk involved in xylitol consumption, more research papers would have been conducted and published in more recent times than the 1980s papers that the webMD statement is based upon.
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- Re: Xylitol and Cancer FocusOnHealth
12 y
10,043
This is a reply to # 1,991,364Hi Saywhydoi,
Thank you for your kind words.
And, YES, I agree that, if there was any real risk in consuming xylitol, then there would be more papers in more recent times than the 1980s papers that the WebMD statement is based on.
Hi Everyone,
I've come across a 1978 R.J. Smith article that may be relevant. A John D. Brunzell who was able to review it here says it contains "a suggestion that xylitol... may be associated with bladder tumors at high levels of ingestion in mice."
The article that Brunzell talks about is "Xylitol: another sweetener turns sour." by Smith, R.J., Science J99: 670-71, 1978.
However the 1978 Smith article is not available online. But, even if it was available (in medical libraries), I wouldn't worry too much about it. If the above statement is just a "suggestion" then it's just a vague, non-specific, questionable opinion without any evidence.
I hope this helps.
FocusOnHealth
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