Blog: Aloe Vera Research Blog
by RisingSun

Aloe Vera:Cancer Tumors Regress...in 29/30 Participants

ANTI-CANCER

Several scientific studies have found evidence that aloe may have anti-cancer abilities.

Shamaan et al.12 found that vitamin C and Aloe vera extract were able to reduce the severity of chemical hepatocarcinogenesis, which is the development of liver cancer. In this study, the researchers chemically induced liver cancer in rats and then examined the severity of the process of cancer development. When vitamin C or Aloe vera supplements were given to the cancer-induced rats, these previously increased biochemical indicators of cancer were suppressed. In particular, plasma levels of the enzyme gamma-glutamyl transpeptidase were found to be "reduced as early as 1 month with Aloe vera gel supplementation and 2 months with vitamin C supplementation."


Date:   3/13/2005 5:12:16 PM   ( 19 y ) ... viewed 6449 times

There is mounting evidence that free radicals play an important role in the initiation and progression of cancer. A study completed by Desai et al.9 investigated the antioxidant activity of Roidex, a combination of squalene, vitamin E, and Aloe vera. The purpose of this study was to determine whether this formulation is able to prevent the development of chemically induced cancer and to cause regression of any tumors already formed in a mouse skin model. To study the cancer prevention ability of this mixture, skin tumors were chemically induce in 50 mice. The mice were treated with either mineral oil, 5% squalene, or Roidex. The researchers found that at the end of the prevention study, "there was a 33.34% incidence to tumors in the mineral oil-treatment group, and 26.67% in the 5% squalene and Roidex groups." To study the ability of Roidex to cause tumor regression, mice with tumors were selected for testing. The results were "a regression of 33.34% of the tumors in the Roidex-treated group (39 tumors to 26 tumors) compared to the non-treated group whose tumors regressed only 3.44% (29 tumors to 28 tumors)." In summary, this study found that a combination of vitamin E and Aloe vera reduced the incidence of tumors and caused tumor regression in induced cancer in mice.

References:



1. Byeon SW, et al., "Aloe barbadensis extracts reduce the production of interleukin-10 after exposure to ultraviolet radiation" J Invest Dermatol, 1998 May;110(5):811-7

2. Chithra P, et al., "Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats" J Ethnopharmacol, 1998 Jan;59(3):179-86

3. Chithra P, et al., "Influence of aloe vera on the healing of dermal wounds in diabetic rats" J Ethnopharmacol, 1998 Jan;59(3):195-201

4. Chithra P, et al.,"Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats" Mol Cell Biochem, 1998 Apr;181(1-2):71-6

5. Chithra P, et al.,"Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats" Indian J Exp Biol,1998 Sep;36(9):896-901

6. Davis RH, et al., "Anti-inflammatory and wound healing activity of a growth substance in Aloe vera" J Am Podiatr Med Assoc, 1994 Feb;84(2):77-81

7. Davis RH, et al., "Processed Aloe vera administered topically inhibits inflammation" J Am Podiatr Med Assoc, 1989 Aug;79(8):395-7

8. Davis RH, et al., "Wound healing: Oral and topical activity of Aloe vera" J Am Podiatr Med Assoc, 1989 Nov;79(11):559-62

9. Desai KN, et al., "The preventive and therapeutic potential of the squalene-containing compound, Roidex, on tumor promotion and regression" Cancer Lett, 1996 Mar 19;101(1):93-6

10. Odes HS, et al., "A double-blind trial of a celandin, aloe vera and psyllium laxative preparation in adult patients with constipation" Digestion, 1991; 49(2): 65-71

11. Schmidt JM, et al., "Aloe vera dermal wound gel is associated with a delay in wound healing" Obstet Gynecol, 1991 Jul;78(1):115-7

12. Shamaan NA, et al., "Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat" Nutrition, 1998 Nov-Dec;14(11-12):846-52

13. Strickland FM, et al., "Inhibition of UV-induced immune suppression and interleukin-10 production by plant oligosaccharides and polysaccharides" Photochem Photobiol, 1999 Feb;69(2):141-7

14. Strickland FM, et al., "Prevention of ultraviolet radiation-induced suppression of contact and delayed hypersensitivity by Aloe barbadensis gel extract" J Invest Dermatol, 1994 Feb;102(2):197-204

15. Stuart RW, et al., "Upregulation of phagocytosis and candidicidal activity of Macrophages exposed to the immunostimulant acemannan" Int J Immunopharmacol, 1997 Feb;19(2):75-82

16. Sydiskis RJ, et al., "Inactivation of enveloped viruses by anthraquinones extracted from plants" Antimicrob Agents Chemother, 1991 Dec;35(12):2463-6

17. Syed TA, et al., "Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study" Trop Med Int Health, 1996 Aug;1(4):505-9

18. Visuthikosol V, et al., "Effect of aloe vera gel to healing of burn wound a clinical and histologic study" J Med Assoc Thai, 1995 Aug;78(8):403-


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