I think it is always safe to add 1 drop pure to 1 gallon water and shake nd use for all purposes. More than this is always experimental. Some people take 8+ drops pure oregano daily for no real reason and I think that is insane. The only way to safely take a large dose is if the person is using lots of LBB capsules and have no constipation, because when you take oregano, allot of trash is dieing and circultion increased, so you want it going down and out.