I take nattokinase along w/my arrythymic boxer doggie who is off of her presciption meds with herbs,fish oil,iodine,magnesium,etc.Iwould add the 1997 nobel discovery of l-citruline 1000 mg, & l-arginine 6000 mg for nitric oxide for endothelial (blood vessel lining) health (also dramatically reverses impotence). also 1.5 ozs of pomagrnite juice and GLISODIN will clean plaque out (see lef.com for study results)