DMPS and DMSA are called provocation challenge tests. They test, as well as, chelate mercury; But, they are "dangerous", according to Dr. Hal Huggins and Dr. Thomas Levy. Originally used for military personnel who had high amounts of heavy metal exposure, they were designed to get the metals out quick. However, it puts toxic loads of metals on the kidneys. Dr. Hal Huggins told me that he has "seen too many horror stories with DMPS". Even the new lower doses of DMSA being promoted now days can be toxic.
Dr. Thomas Levy is a cardiologist who co-authored Uninformed Consent with Hal Huggins. In the book, Drs. Levy and Huggins discourage the use of [these] synthetic chelators in general, and DMPS in particular. At page 252 they state:
"Heavy metal chelators almost always overaccelerate the detoxification of the post-TDR (total dental revision) patient. DMSA, DMPS, and EDTA can all do this. DMPS is consistently the greatest offender here. Immune declines and clinical illness can result for weeks and sometimes even months after only one injection of DMPS".
Dr. Levy...[says], "DMPS is an unqualified sledge hammer to the immune system." He referred to the administration of DMPS as an "assault". Dr. Levy believes that synthetic chelators should just plain be avoided most of the time. Most patients simply don't need them. http://www.dmpsbackfire.com/dmps/default.shtml
*In recent years, DMSA has become available in much lower doses, and Hal Huggins DDS, MS and Thomas Levy MD, JD now approve of the use of DMSA capsules. Here is what Dr. Levy has to say, "In a nutshell, DMSA is fine if you take enough vitamin C and other antioxidant supplementation so that you are completely free from any negative symptomalogy from the ensuing release of toxins. A particularly good form of vitamin C for this purpose is lipsomal encapsulated vitamin C (livonlabs.com)."
The doctor focuses on ridding the body of mercury fillings, root canals, metals and toxins. The chelation is left up to the patient. I list the known chelators of mercury with dosages. I also have a list of the newest ones that you should do your own research on and/or consult your health care provider before taking. I chelated for four months which I felt was adequate for me.
I asked Dr Boyd Haley about ALA, told him about the other chelators I took to chelate mercury, and that I took ALA 200mg twice daily. I asked about the claims by Cutler that this amount and scheduling of ALA is dangerous. Here is his response:
"ALA is a much needed natural product that is essential for the pyruvate dehyrodgenase complex in the Krebs cycle within the mitochondria. It is only dangerous if you use an excess, then it could behave like a detergent and cause problems." DMPS Challenge Test [is a] urine mercury test before and after a chelation "challenge" with DMPS that liberates mercury stored in body tissues. This is much more accurate and meaningful than plain blood or urine testing. [I do not recommend this test. DMPS and DMSA were originally government military tests designed to get large amounts of heavy metals out of our soldiers. They can be dangerous according to Hal Huggins. Patients can end up bed-ridden for months, on dialysis, some have even died! Note: Hal is now using small doses of DMSA, which is much safer than DMPS and seems to work well for some patients. If you do decide to take DMSA, best to consult a health care provider or physician.]
[F]requently...urine... is tested after an intravenous infusion of DMPS chelation. The urine test result, however, is commonly reported incorrectly on a form using reference ranges derived from urine collected without a prior provocative chelation using DMPS or any other chelator. The result therefore, is reported incorrectly and deceptively appears to be very high. Using a single dose of DMSA by mouth on an empty stomach with a glass of water, preferably in the morning before breakfast, and then carefully collecting all urine for six hours, a wide range of toxic metals (mercury, lead, arsenic, cadmium, nickel and others) are measured by the King James Omegatech Laboratory, relative to urine creatinine. ... do[es] not use 24 hour urines because they have been proven to have much greater collection errors. If the mercury level measured with this test is less than 5 micrograms per gram of urine creatinine (which is close to the mean or average level for all Americans), there is probably no mercury toxicity. The more concentrated the urine, as occurs with fasting, the higher the metal concentrations, which results in more accurate testing. By reporting mercury relative to urine creatinine, which is excreted at a fairly constant rate throughout the day, correction for variable dilution with fluid intake occurs. A reading of from 6 to 8 for mercury is suspicious but still doubtful. If the result is higher than 8, I would suggest a course of DMSA by mouth, with repeat testing every 3 months until the level is below 5. All chelation, including DMSA, should be stopped at least 3 weeks before follow-up testing to allow equilibration throughout in the body. I have posted the reference ranges used in my practice on this Website at the link below to help you in your own interpretation. These are the ranges derived from my own patients using the King James Laboratory, using the above method. http://www.drcranton.com/mercury/interpretation.htm .... Any doctor or dentist can prescribe DMSA, which can be obtained generically at a reasonable cost from Wellness Health and Pharmaceuticals: 2800 South 18th St., Birmingham, AL 35209 PHONE:(205)879-6551 (800)-227-2627 FAX:(205)871-2568 (800)-369-0302 EMAIL: rharbin@e-pages.com
The usual dose is 500 mg fasting on arising with a glass or two of water (coffee or tea is OK). Eat no food for 45 minutes. This is done three days per week, Mon. Wed. Fri. If you miss a dose, take it the next day. DMSA is also available at any pharmacy as "Chemet" or "succimer," but only as 100 mg capsules and is much more expensive than the generic form.
http://www.drcranton.com/mercury/mercurytesting.htm
Everyone has some mercury in their body. If DMPS, DMSA or any other mercury chelator is given, mercury excretion increases greatly. That will always occur, even in people with relatively low and nontoxic levels of mercury. We need to know whether or not the amount of mercury detected is enough to cause symptoms of ill health. Is it a toxic level? The only way to do that is to compare measured results with ranges found using exactly the same type of provocative chelation on large number of people who do not have symptoms of mercury toxicity. Many laboratories do not seem able to provide that type of honest report. ....
To correctly interpret a test result and to know if you really do have a mercury problem, you must know the range of mercury levels measured by that same laboratory in the urines from a large population of typical Americans who suffer no symptoms of toxicity, and they must be tested after exactly the same method of provocative testing and specimen collection used in your own testing. Ask the laboratory to provide you with the mean (average) level and the standard deviation of test results from a series of at least 100 consecutive test subjects using the same protocol you used. At the mean (average) level, approximately 50% of all people tested will have more mercury. At the mean level plus one standard deviation (SD), approximately 16% will be higher. At the mean plus 2 SD, 2.5 % will be higher. At mean plus 3 SD, less than 1% will be higher. Those percentages will vary somewhat with the distribution of values, but this method allows an approximation. ....
Accurate mercury testing is very difficult and not all labs have good quality control.
One laboratory...[the Author] recommend[s] has consistently performed accurate testing for...patients, ...The King James Omegatech Medical Laboratory in Cleveland, Ohio. Their Internet website address and phone number is listed below. Any doctor can use their services. But, ...[He] do[es] not blindly accept the reference ranges on the laboratory report. ...[He]...personally [has] computed the means and SD for each metal using a large number of test results from patients with no symptoms of metal toxicity and established the 97th percentile as the reference range (somewhat lower for mercury). http://www.kingjamesomegatech-lab.com
In [the Author's] opinion, DMPS is obsolete no longer has a place in medicine. [He has] communicated with many patients who received DMPS elsewhere and were made quite sick by it. Even if DMPS is used, it can effectively be given by mouth without intravenous infusions. EDTA is a very weak chelator of mercury and is not an effective treatment for mercury toxicity. [He] recommends DMSA, which can be given by mouth, is safer, more effective, and much less expensive. ....
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