Re: possible alternative to IP6?

http://www.lewrockwell.com/sardi/sardi39.html


states:

In 2001 Food and Drug Administration researchers reported that 8 of 12 chelating agents tested were mutagenic (caused gene mutations). Among the four non-toxic chelators was IP6. [Whittaker P, Environmental and Molecular Mutagenesis 38: 347–56, 2001]

Looked into [Whittaker P, Environmental and Molecular Mutagenesis 38: 347–56, 2001] and found:


http://www3.interscience.wiley.com/cgi-bin/abstract/89011884/ABSTRACT?CRETRY=...


Abstract
To further study the mechanism of observed iron mutagenicity and cellular toxicity, a number of different iron chelators were evaluated to select a compound that was not mutagenic and had limited toxicity to mouse lymphoma cells. A series of iron chelators including those used clinically, those under development for clinical applications, and those used in nonclinical applications were evaluated. The mutagenic activity of the iron chelators was assessed in L5178Y mouse lymphoma cells. Eight of the 12 iron chelators that were tested induced mutagenic responses both with and without the addition of S9. Among those chelators used clinically or developed for clinical use, the only compound that did not induce a mutagenic response was the starch deferoxamine conjugate. In contrast, deferoxamine mesylate showed the highest toxicity in this group of chemicals and the concentrations leading to toxicity and mutagenicity between the activated and nonactivated assays were not significantly different. The other three chelators that were not mutagenic were Na2EDTA, phytic acid, and ferrozine. Environ. Mol. Mutagen. 38:347-356, 2001. Published 2001 Wiley-Liss, Inc.


Then searched [Environ. Mol. Mutagen. 38:347-356, 2001. Published 2001 Wiley-Liss, Inc.] for a list of the twelve tested- but nada.

So these were concluded to be non-toxic:

Na2EDTA: pretty much know what this is.

phytic acid: aka IP6

deferoxamine conjugate: had to look it up.

Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.


http://reference.md/files/C068/mC068460.html


Anyone have a clue what ferrozine is? Searches pull up nothing comprehensive.

I'd love to know just what those twelve known chelators are/were. Or the eight which were proven toxic. Wonder if any are natural substances also.