My husband removed 13 but the directions say 1-2 large ones or up to 25 small ones. He only needed one 20 minute app. that's the great part. Other ones he had tried in the past, you had to apply everyday and we didn't see any results. But the #1 Natural mole and wart remover did the job! He said it stung for about 5 minutes then he didn't feel anything after that.