That said, sometimes the liver dumps a lot of unbound toxins into your system and that will irritate a lot of other things. Best is to bind that toxin with some water soluble fiber, Konjacu is best http://www.konjakfoods.com but for now Benefiber will do and you can get that just about anywhere.
Milk Thistle and MSM will help; dosage for MSM is under my profile.
Once you get some relieve then you MUST start to look at where this toxicity is coming from and one option may be parasites.