For me any anger or irritation where everything pisses me off has more to do with the detox part of the colon cleansing. I've had it on Oxypowder , the first few days of the Master-Cleanse and since the Liver Flush is partly a Colon Cleanse figuring the preparation and the epsons getting rid of everything.... I guess just toxins in general..not neccesarily the actual flush or the stones.