Side effects from properly prescribed meds = 4th leading cause of death in USA

Amazing. That figure does not include over doses, etc. It is simple from the side effects!

There are a few extra good reading links at the end of this:

180,000 people die each year partly as a result of Iatrogenic Injury. The equivalent of three jumbo jet crashes every 2 days. 20% of all patients admitted to a university hospital suffered iatrogenic injury. 36 % of those admitted to a teaching hospital suffered an iatrogenic event, of which 25% were serious or life threatening. 64 % of cardiac arrests at a teaching hospital were preventable. Most were due to use of medications.
Leape LL, Error in Medicine. JAMA Dec. 21, 1994; 272(23): 1851-7
Medical Malpractice is the 3rd leading cause of Preventable Death in the United States. Malpractice is responsible for the deaths of 80,000 people annually, one every 7 minutes. This does not include iatrogenic injury.
Public Citizen Magazine (A Ralph Nader Publication) 1994; May/June

Of 1,047 patients during the study. Adverse Events were identified by healthcare personnel in 480 patients, of which 185 resulted in Serious Complications ranging from Temporary Disability to Death.
Andrews LB; Stocking C; Krizek T; Gottlieb L; Krizek C; Vargish T; Siegler M; An alternative strategy for studying Adverse Events in medical care. Lancet 1997;349:309-313.

"Only about 15% of all medical interventions are supported by scientific evidence. This is partly because only 1% of the articles written in medical journals are scientifically sound." D. Eddy, M.D., Ph.D.
Smith R, Where is the wisdom?. BMJ 1991; 303(6806):798-9

Therapeutic drug use (not illicit drug use) each year; Kills as many as 198,815 people, puts 8.8 million people in hospitals, accounts for 28% of all hospital admissions, and costs as much as $182 billion dollars.
American Medical News. Jan 15, 1996, p.11


Bookmarks in this document:

Adverse Drug Reactions
Problems with the Drug Approval Process
Hospital Reactions
Cost Of Drug-Related Illness Is Immense
Medication For Elderly People Often Inappropriate
Drug Information not Always Accurate
Adverse Drug Reactions Are Frequent And Costly
Another Study Finds Hospital Errors Injure Patients
Cost And Human Toll Of Medical Errors
Incorrect Information In PDR Could Affect Overdose Management
Many Are Treated but Few Are Healed

Other DrugIntel pages on related topics:

Iatrogenic causes of Death
Adverse Drug Reactions, Adverse Drug Events,
and Medication Errors are a
Leading Cause of Death in USA
Statistics on Adverse Drug Reactions: Incidence
Pharmacogenetics - Many are treated but few are healed


Preventable drug-related morbidity and mortality was estimated to cost $76.6 billion in the ambulatory setting in the United States. The largest component of this total cost was associated with drug-related hospitalizations. The estimated cost ranged from a conservative estimate of $30.1 to $136.8 billion in a worst-case scenario.
Johnson JA, Bootman JL, Drug-related morbidity and mortality. A cost-of-illness model., Arch Intern Med 1995; 155(18):1949-56

We estimated that the annual additional costs associated with preventable [adverse drug events]...were $2.8 million and that the costs associated with all [adverse drug events] were $5.6 million.
Bates DW; Spell N; Cullen DJ; Burdick E; Laird N; Petersen LA; Small SD; Sweitzer BJ; Leape LL; The costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group. JAMA1997; 277(4):307-11

Drug errors not only increase costs, but also significantly prolong hospital stays and increase the risk of death almost 2-fold.
Classen DC; Pestotnik SL; Evans RS; Lloyd JF; Burke JP; Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality JAMA 1997; 277(4):301-6

Several easily identifiable factors are associated with a large proportion of medical prescribing errors. Factors commonly associated with errors in prescribing medications were inadequate knowledge or use of knowledge regarding drug therapy; presence of important patient factors related to drug therapy such as age, impaired renal function, and drug allergy; the need for calculation of drug doses; and specialized dosage formulation characteristics and medication prescribing nomenclature. Adverse drug events in hospitalized patients are "...countable, dangerous and evaluable events, not just a collection of unhappy accidents that strike, like cosmic rays, in ways that we cannot predict or understand. In an era of constrained resources, it is vital to remember that [drug errors] in hospitals are common, costly and preventable in many cases."
Lesar TS; Briceland L; Stein DS; Factors related to errors in medication prescribing JAMA 1997; 277(4):312-7

Adverse Drug Reactions:
17% of ALL Hospital Admissions are caused by the Side Effects of Drugs administered by an MD
8 million people are hospitalized annually for diseases brought on by prescription drugs
Adverse Drug Reactions are responsible for 100,000 deaths yearly
Prescription Drug-Related Diseases and Death cost the US $77 BILLION dollars Annually
Archives of Internal Medicine; Oct 9, 1995

Problems with the Drug Approval Process:

Although the review process is comprehensive, it is estimated that over 51% of approved drugs have serious side effects not detected before marketing approval.

Moore T, Psaty B, Furberg C. Time to act on drug safety. JAMA 1998;279(19):1571-3.

This may be because the studies conducted did not last long enough for the effects to become manifest or because patients likely to experience problems are not always enrolled in the
trials. In addition, in clinical trials often fewer than 3000 patients are given a new drug, making it likely that an ADR with an incidence of 1 in 10 000 will remain undetected.

General policy topics -- adverse drug reaction monitoring. WHO Drug Info 1997;11(1):1-4.



Hospital Reactions
Nosocomial infections (aka "hospital generated") strike 1 out of 10 hospitalized patients, or 2.5 MILLION people per year :

The average nosocomial infection costs $1,800 to clear up, or $4 BILLION dollars yearly
Nosocomial infections cause 20,000 deaths annually and are a contributing factor in another 60,000 deaths per year
"Total Wellness" by Dr. Joseph Pizzorno



Cost Of Drug-Related Illness Is Immense
TUCSON, ARIZONA. The sale of Prescription Medicines in the United States exceeded $73 billion in 1994. Two researchers from the University of Arizona conclude that preventable illness and death from the misuse of these medicines cost the American economy over $75 billion a year; if lost productivity is included the cost rises to between $138 billion and $182 billion annually. The researchers point out that the purpose of prescribing pharmaceutical drugs is to treat disease successfully - not to cause more problems. They estimate that this purpose is achieved in less than 40 per cent of all cases. More than 60 per cent of all people prescribed pharmaceutical drugs end up with a drug-related problem which results in almost nine million hospital admissions a year at an estimated cost of $47.4 billion. As a matter of fact, it is estimated that more than 28 per cent of all hospital admissions in 1992 were due to drug-related illness and that somewhere between 80,000 and 200,000 people died from complications involving prescription medicines. In comparison, it is estimated that the direct cost of diabetes to the American economy was $45 billion in 1992 and that of heart disease was $117 billion. The researchers conclude that drug-related illness and death should be considered one of the leading diseases in the United States.

Johnson, Jeffrey A. and Bootman, J. Lyle. Drug-related morbidity and mortality. Archives of Internal Medicine, Vol. 155, October 9, 1995, pp. 1949-56



Medication For Elderly People Often Inappropriate
SALFORD, ENGLAND. Doctors at the teaching hospital affiliated with the University of Manchester have found that many elderly patients have the wrong drugs prescribed and many are suffering from adverse drug reactions. During a 10-week period the medications of 416 elderly (median age of 76 years) patients admitted to the hospital were evaluated in detail. Only 8% of the patients were taking no drugs at all; the remaining 381 patients took a total of 1,348 drugs between them. 48 of the patients had been prescribed drugs which were clearly contra-indicated, 155 of the patients were on medication which was unnecessary, and 103 patients experienced adverse reactions to the drugs they were on. The authors of the study conclude that appropriate prescribing of drugs by doctors could go a long way towards improving the quality of life of elderly people.
Age and Aging, July 1992, pp. 294-300



Drug Information Not Always Accurate
SAN DIEGO, CALIFORNIA. Pharmaceutical companies now spend $10 billion every year on promoting their drugs. About 25 per cent of this amount goes to pay an army of drug salesmen who regularly visit doctors to push the latest products. It is estimated that there is one drug salesman for every 10 to 30 medical doctors in the United States. A common practice is to provide doctors with a free lunch while they listen to the salesman's presentation. Now two medical doctors at the San Diego School of Medicine report that the statements made by the salesmen at these "lunch conferences" are not always accurate. The researchers taped and later analyzed all statements made during 13 lunches attended by an average audience of 33 resident physicians and medical students. They found that 11 per cent of the statements made about the drugs being promoted were inaccurate. All the false statements cast the drugs in a more favourable light than warranted. Two of the false statements could actually lead to serious complications if accepted at face value. A survey of the attending doctors showed that 85 per cent of them thought that the drug salesmen provided useful information and 37 per cent of them said that the information they provided influenced which drugs they prescribed to their patients.

Ziegler, Michael G., et al. The accuracy of drug information from pharmaceutical sales representatives. Journal of the American Medical Association, Vol. 273, No. 16, April 26, 1995, pp. 1296-98



Adverse Drug Reactions are Frequent and Costly
SALT LAKE CITY, UTAH. It is estimated that adverse drug reactions kill about 140,000 people in the United States every year and that from 3 per cent to 28 per cent of all hospital admissions are related to adverse drug reactions. Now researchers at the LDS Hospital (affiliated with the Utah School of Medicine) report that adverse drug events within hospitals are frequent, costly, and often deadly. Their three-year study involved 1580 patients who had suffered an adverse drug event (ADE) while hospitalized and 20,197 matched controls. The researchers found that ADE victims had a three times higher crude death rate than did controls; the length of their hospital stay was 70 per cent longer and the average cost of their stay was $10,010 versus $5,355 for controls. Among the drugs most commonly involved in adverse events were morphine, digoxin, meperidine, acetaminophen (Tylenol, Paracetamol), warfarin, and vancomycin. The patients who experienced an ADE were given an average of 12 different drugs prior to the adverse event. Cardiac arrhythmias were common results of ADEs and were associated with an excess hospitalization cost of over $4,000 and excess length of stay of almost four days. The LDS Hospital study showed that about 2.4 per cent of all hospital patients develop an ADE. Other studies have shown a rate of 6.5 per cent. Extrapolating the 2.4 per cent rate to the 32 million yearly hospital admissions in the United States results in an estimate that over 770,000 patients in American hospitals experience an adverse drug reaction. Direct hospital costs to treat these ADEs are estimated at $1.56 billion annually. If it is assumed that the national average rate of ADEs is closer to 6.5 per cent, then it can be estimated that the total cost of treating adverse drug events is about $79 billion every year. The LDS Hospital study concludes that 50 per cent of all adverse drug events occurring in American hospitals are preventable. A major cause of the events is the failure to properly calculate the drug dosage based on the patient's weight and calculated renal (kidney) function.
Classen, David C., et al. Adverse drug events in hospitalized patients. Journal of the American Medical Association, Vol. 277, No. 4, January 22/29, 1997, pp. 301-06



Another Study Finds Hospital Errors Injure Patients
BACKGROUND: Data about the frequency of adverse events related to inappropriate care in hospitals come from studies of medical records as if they represented a true record of adverse events. In a prospective, observational design we analysed discussion of adverse events during the care of all patients admitted to three units of a large, urban teaching hospital affiliated to a university medical school. Discussion took place during routine clinical meetings. We undertook the study to enhance understanding of the incidence and scope of adverse events as a basis for preventing them.

METHODS: Ethnographers trained in qualitative observational research attended day-shift, weekday, regularly scheduled attending rounds, residents' work rounds, nursing shift changes, case conferences, and other scheduled meetings in three study units as well as various departmental and section meetings. They recorded all adverse events during patient care discussed at these meetings and developed a classification scheme to code the data. Data were collected about health-care providers' own assessments about the appropriateness of the care that patients received to assess the nature and impact of adverse events and how health-care providers and patients responded to the adverse events.

FINDINGS: Of the 1047 patients in the study, 185 (17.7%) were said to have had at least one serious adverse event; having an initial event was linked to the seriousness of the patient's underlying illness. Patients with long stays in hospital had more adverse events than those with short stays. The likelihood of experiencing an adverse event increased about 6% for each day of hospital stay, 37.8% of adverse events were caused by an individual, 15.6% had interactive causes, and 9.8% were due to administrative decisions. Although 17.7% of patients experienced serious events that led to longer hospital stays and increased costs to the patients, only 1.2% (13) of the 1047 patients made claims for compensation.

INTERPRETATION: This study shows that there is a wide range of potential causes of adverse events that should be considered, and that careful attention must be paid to errors with interactive or administrative causes. Healthcare providers' own discussions of adverse events can be a good source of data for proactive error prevention. 45% of patients suffered inappropriate care resulting in complications or medical injury caused by an action or inaction of a hospital staff member
17.7% had at least one serious adverse event
Patients with long stays in hospital had more adverse events than those with short stays. The likelihood of experiencing an adverse event increased about 6% for each day of hospital stay
37.8% of adverse events were caused by an individual
15.6% had interactive causes
and 9.8% were due to administrative decisions
17.7% of patients experienced serious events that led to longer hospital stays and increased costs to the patients, only 1.2% (13) of the 1047 patients made claims for compensation.
Andrews LB, Stocking C, Krizek T, Gottlieb L, Krizek C, Vargisn T, Siegler M. An alternative strategy for studying adverse events in medical care. Lancet 349: 309-313 (1997)





Cost And Human Toll Of Medical Errors Estimated
WESTPORT, Oct 10 (Reuters) - The number of injuries attributable to medical errors in the inpatient setting may top 3 million and cost more than $200 billion, according to data presented Thursday in New York during a media briefing, "Finding Cures for Medical Error," sponsored by the AMA's National Patient Safety Foundation. Dr. Lucian Leape, of Harvard School of Public Health, presented data from a University of Chicago study in which investigators used "...an on-site, real-time observational method of collecting data," an AMA press release explains. The Chicago study also revealed, according to the press release, that "...serious injuries due to errors occur in over 17 percent of patients admitted to intensive care and surgical units at a teaching hospital." Dr. Leape said, "When this figure is extrapolated to the hospital and then the nation as a while, the increase of injury can reach into the millions with costs climbing into the billions." He added that past studies based on data taken largely from medical records probably underestimated the magnitude of the problem. Meanwhile, results of a Louis Harris poll presented during the briefing showed that more than 100 million Americans have been directly "touched" by a medical error at some point. In the random survey, 42% of respondees said that they had been "...involved in a situation where a medical mistake was made, either personally or through a friend or relative," according to an AMA press release. Despite this, most Americans think healthcare is relatively safe. "Overall, including those affected by a mistake and those who have not been, the survey reveals a public that considers the healthcare environment to be 'moderately safe,''' officials with the National Patient Safety Foundation said in the press statement.



Incorrect Information In PDR Could Affect Overdose Management
WESTPORT, Feb 07 (Reuters) - Physicians who rely on the Physicians' Desk Reference (PDR) for overdose management advice may be using deficient information that could lead to "unnecessary morbidity or mortality," report researchers in the February issue of the Annals of Emergency Medicine. The researchers at the University of California surveyed physicians who called the San Francisco Bay Area Regional Poison Control Center during 1 month, to determine their use of the PDR for overdose information. They found that 50% of the physicians did so in the preceding 12 months. The investigators also compared PDR overdose treatment recommendations with five current major toxicology references. They report that "[o]f the 20 PDR entries [studied], 16 (80%) had at least one deficiency, and 5 (25%) had two or more deficiencies. Thirteen (65%) omitted an indicated specific treatment, three (15%) recommended contraindicated treatments, and four (20%) advised ineffective treatments with potential for harm." Specifically, the researchers note that the Elavil entry remains unchanged since 1973, and the Sinequan entry since 1977. "We did find quite serious discrepancies between toxicologic management and the guidelines given in the PDR," one of the authors, Dr. Walter H. Mullen, told Reuters Health. "I think there are two things that can be done by the FDA. First, they can eliminate that section [on overdose management in the drug labeling guidelines] if there's difficulty keeping it up-to-date, or alternatively, they can have some periodic update of the management guidelines to reflect current standards. The point of the article is to alert physicians that the information in the PDR may not be as accurate as we'd like and perhaps it's not, at this time, the best reference for overdose management."
Ann Emerg Med 1997;29:255-261.

Many Are Treated, but Few Are Healed

"The vast majority of drugs - more than 90 per cent - only work in 30 or 50 per cent of the people," Dr Roses said. "I wouldn't say that most drugs don't work. I would say that most drugs work in 30 to 50 per cent of people. Drugs out there on the market work, but they don't work in everybody."


Drugs for Alzheimer's disease work in fewer than one in three patients, whereas those for cancer are only effective in a quarter of patients. Drugs for migraines, for osteoporosis, and Arthritis work in about half the patients, Dr Roses said. Most drugs work in fewer than one in two patients mainly because the recipients carry genes that interfere in some way with the medicine, he said.

http://www.drugintel.com/pharma/adverse_drug_reactions.htm
http://www.dr-schulze.com/2005-01_Newsletter.asp?page=1
http://www.torontofreepress.com/2004/health122104.htm
http://www.bobmantz.com

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