i don't know about proof all i can offer is empirical by my friends usage on her autistic boy she has had amazing results and the urine tests she does on him shows heavy metals esp. mercury. i have been on it i think about 2 weeks and after about 2 days i noticed the severe pain in my neck and shoulders start to literally break up, you could hear crunching when i moved my arms and neck... now it is 97% gone.