Taking the pau d arco does work good for me, but I can't take credit for the kefir. I think Robbie told you that. I'm not able to take probiotics, they all make me ill.
The first week that I took colosan, I took it first thing in the morning an hour and half before food. Again in the late afternoon, and an hour and a half before eating dinner.
After the first week, you go on a maintainance program of one to two times weekly. It's important to take it on an empty stomach at least an hour and a half before eating.