The P&B is great for cleaning the colon, but as the toxins are released, you need something to keep them moving out before they are reabsorbed into your blood stream. When I mixed the P&B with the MC, I started with 1/day and used the tea as described in the Master-Cleanse booklet. Then I increased to 2/day, and that was the most I could take and still keep things "moving along". Your experience will surely be different, but for now, gettng things moving should be your top priority.