I am going to start my cleanse tomorrow and I am on prescriptionmedication and will be for at least another month.I don't really see how the medication will interfer with the cleanse. The cleanse is to rid your body of impurities, waste, and toxins. Obviously the medication is something that your body needs to heal. I personally don't consider prescription medications to be toxins. The medications is helping to rid your body of some unwanted sickness that is damaging your body on the cellular level. I think they will work very well together