I have to say that I tried about 3 different cleansing fasts and numerous herbal remedies (echinacea, thyme, dong quai, lavender, oat straw) and have had great success with B5. I started it about a year ago and have had consistently clear skin since, for the fist time in 20 years. I take Milk Thistle regularly as well as Kombucha, but I know that the B5 works. Maybe B5 is a nutrient that has "washed" out of modern diets and that's why Acne is so bad these days. I don't know why it works. I know the skin is a messenger for the insides. I think B5 has made my insides happier. It certainly had made me feel more positive about myself. I haven't had any side effects with it either and I find it to be fairly inexpensive compared to what I was spending on other supplements and topical remedies.