The shot totally messed up my system. I had no desire, gained weight, was moody, suffered migraines, etc. And I started to get eczema around the time I began depo provera, though I can't say for sure if this caused it or not, but it all happened at the same time.
All you ladies who are reading this posting and pondering the many birth control options, please consider looking into natural family planning. There are professionals all over the country today who can teach the technique, and there are several good books out there. I have not taken any chemical birth control in over a year and I have not gotten pregnant. Once you start to understand your cycle it's really easy to know when you're at risk of pregnancy. I have also learned a ton about my own body in the meantime.