Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?

“Post-COVID-19 syndrome is well explained in its pathogenesis and clinical manifestation, with cholinergic neuromodulation disorder due to partial or complete blockage of nicotinic acetylcholine receptors by the SARS-CoV-2 virus playing a potentially important role. In all four of the cases we studied, transcutaneous use of nicotine led to a near immediate improvement in symptoms and rapid restitutio ad integrum. The course of symptom improvement was as distinct as the clinical presentation of post-COVID-19 syndrome in each patient. The ease of implementation and the good controllability of the minor side effects make randomized, double-blinded studies to investigate this treatment option more closely seem feasible. Based on the results of this case study, this treatment option—using nicotine patches to combat long-haul COVID—seems far superior to the time-consuming, often underwhelming or disappointing, costly and complex rehabilitation measures currently available to these patients.”


“Since nicotine may protect nAChRs from viral attachment, therapeutic nicotine application was proposed in the management of acute COVID-19 infections (Changeux et al. 2020). This argument is convincingly supported by the cohort study of Hippisley-Cox et al. (2020), with a total of 8.28 million participants (including 19,486 confirmed COVID-19 cases), showing lower odds for COVID-19 infection and COVID-19-related ICU stay in association with smoking (Hippisley-Cox et al. 2020).”

As seen in this article, the spike proteins work as more of a binder to the ACE 2 receptors & DNA sections (nACHR) receptors - nicotine works essentially to kick off these spike proteins, my theory would be that when these spike proteins are removed from those receptors, causing the management of symptoms. And potentially the ability for your body to eliminate the spike proteins.
As mentioned for a detox protocol what are the supplements you have taken?


https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-023-00104-7