a warning about water soluble c60

Erica Khan shared a link.
October 15 at 11:37 AM

For anyone contemplating the use of the new "water-soluble" C60 products (i.e., Buckyol, YES Labs, etc.), please bear in mind that these water-soluble C60's are HIGHLY EXPERIMENTAL at this time. Unlike the liposomal pristine C60 used in the Baati rat study which demonstrated a complete lack of toxicity for C60 prepared in this way, the water-solubilized C60's are quite different, and being in the nanoscale size range with the ability to slip past the defense of cellular membranes and reach all parts of the cell including the nucleus and DNA, extreme caution is warranted before making any assumptions about their safety. There are many ways to water-solubulize C60, but most typically it involves attaching "functional" molecular groups to it through a chemical reaction. These additions allow it to disperse in water when normally it would clump, but they also change the C60 molecule's size, shape and surface charge. Although these changes may seem minor, the fact that they are operating at the level of nano scale makes them highly significant due to their abilty to alter cellular signaling and functioning in ways that are often unpredictable and detrimental. The concentration, dosing and toxicity profiles of these numerous versions of water-soluble C60's have not been established. Although they have been shown in many cases to be very potent free radical scavengers, and there may in fact be some therapeutic indication for them in conditions of mitichondrial dysfunction and oxidative stress such as Alzheimer's and cancer, they have also been shown to cause mitochondrial dysfunction and premature cell death in healthy cells. Taking them prophylactically (as a "preventative") without understanding the ADME profile (absorption, distribution, metabolism, excretion) for each potential variant of a functionalized, water-soluble C60 is highly premature and speculative, and IMO irresponsible and greedy on behalf of the marketers who are promoting them. Here is one of several studies that should give one pause before succumbing to the latest marketing hype:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949473/?fbclid=IwAR1mtQfFanhYGam06Rh5xOGlQQ91v4JVB9TzQCh0E3WvIgR3R5MeZvwE7m8 Tweet