Magnesium sulfate is choleretic and cholagogue

Magnesium sulfate is choleretic


This study provides direct evidence that the mechanism of magnesium sulfate-stimulated gallbladder contraction occurs through the release of CCK, and shows a close correlation between CCK release and contraction of the gallbladder.


Correlation Between Gallbladder Size and Release of Cholecystokinin After Oral Magnesium Sulfate in Man

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1352753/



Abstract

In order to determine the effect of oral magnesium sulfate on gallbladder contraction and release of cholecystokinin (CCK) in man, magnesium sulfate (25 g in 100 ml distilled water) was given by mouth to five fasting adult male volunteers. Plasma samples were collected for measurement of CCK by a specific radioimmunoassay. Gallbladder volumes were determined from sonograms obtained from a phased-array real-time ultrasound scanner. Basal concentrations of CCK (82.2 ± 10.1 pg/ml) increased significantly at 20 minutes after oral magnesium sulfate (113.8 ± 7.1 pg/ml), and reached a maximal value at 50 minutes (150.0 ± 42.0 pg/ml). The mean basal volume of the gallbladder was 30.8 ± 5.3 cm3 and maximum reduction of gallbladder volume (to one third of original) was achieved at 50 minutes after ingestion of magnesium sulfate. Linear regression analysis showed a close correlation (r = -0.9337) between plasma concentrations of CCK and gallbladder size in response to magnesium sulfate. Oral magnesium sulfate also caused a significant increase in serum gastrin (from basal of 51.4 ± 9.9 pg/ml to 69.8 ± 15.5 pg/ml at 5 min); there was no significant correlation between gastrin release and gallbladder contraction. This study provides direct evidence that the mechanism of magnesium sulfate-stimulated gallbladder contraction occurs through the release of CCK, and shows a close correlation between CCK release and contraction of the gallbladder.




Comparison of the cholecystokinetic and choleretic actions of cholecystokinin, sorbitol, olive oil and magnesium sulfate
http://www.ncbi.nlm.nih.gov/pubmed/14433473




Effect of cholagogues on the volume of the gallbladder of dogs.
http://www.ncbi.nlm.nih.gov/pubmed/8745254
The results indicate that magnesium sulphate and clanobutin exert a direct effect on the motor activity of the gallbladder.





Effects of lorglumide and atropine on MgSO(4)-induced gallbladder emptying in conscious dogs.

http://www.ncbi.nlm.nih.gov/pubmed/11020363
The sustained contraction of the gallbladder in response to the optimal dose of MgSO4 can be explained by an additive effect of the cholecystokinin release and a cholinergic trigger mechanism. Ultrasonography and MgSO4 stimulation proved to be a valuable technique for examination of gallbladder motility.




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