I haven't personally tried, but my aunt is having microcirculation therapy for her diabetic foot. She uses this product called d'oxyva. I am not quite sure, but the premise is introducing medical grade vaporized CO2 through the skin. And I guess most of us know, elevated CO2 levels in the body triggers the release and delivery of more oxygen (through the blood). And oxygenated blood as it implies, carries not only oxygen but as well as much needed nutrients. Toodles!