Substances that Inhibit
Phase 1
detoxification
Note
: In general, inhibition of detoxification is not desired. In the case of Gilbert's Syndrome,
there is an exception to Phase 1 inhibitors, as at a certain level it can allow
Phase II detox to
keep up with it.
Drugs:
benzodiazepines
;
antihistamines
;
cimetidine
and other stomach
-
acid secretion blocking
drugs;
ketoconazole
;
sulfaphenazole
Phytochemicals in
Foods:
naringenin
from grapefruit juice;
curcumin
from turmeric;
capsaicin
form chili pepper;
eugenol
from clove oil;
quercetin
from onions