Serrapeptase, Nattokinase and Lumbrokinase might be helpful but not really directed enough when taken orally. Using DMSO on the skin would be helpful but needs to be handled carefully because it is a solvent which causes anything on the skin to enter into the skin. That includes bacteria and anything else on the skin. Therefore the skin would need to be cleaned thoroughly and the area sterilized before using DMSO. Do not use a finger to apply! Use some other implement such as the handle of a sterilized spoon or something like that. Combining DMSO with the previously mentioned enzymes might be helpful. However start very slowly with tiny doses to check the effect.
Vitamin C would be helpful and so would the amino acids needed for collagen formation. Making a salve using these might be helpful. DMSO would force them into the skin but combining all of this is difficult as I have tried DMSO gel with vit c and amino acids and it became liquid which runs off the skin.
Iodine is meant to be effective too. Lugols stains so potassium Iodide might be worth trying if the skin area is visible as Lugols would stain brown.