cold Hands and Feet =Raynauds,Canker sores - L-Lysine taken daily should improve this symptom, Gut and digestive issues sound IBS like= you said you are controlling it and that is about all you can do via diet.about 60% of patients are able too check out fodmap diet might also help.perhaps do some food sensitivity and food allergy testing.avoid foods that can cause a reaction. Excema - coconut oil and a tiny bit of tee tree oil applied twice daily should improve if you do this along with avoiding said foods Get your bloodwork tested see were your serum protiens and immunoglobulins are at- IgG - plus subclasses,IgA IgM and IgE.- good luck