Infertility in Males and Females

Bisphenol a has been found to be adversely affecting male genital development, subsequently leading to compromised fertility health. One study examined the effects of BPA on the distance between the genitalia and the anus in males, known as the Anogenital distance (AGD). AGD is very important biologically for a number of reasons, and plays a prominent role in the health of one’s fertility. Researchers found that parental exposure to BPA during pregnancy was associated with shortened AGD in male offspring. In other words, high level BPA exposure led to offspring with AGD defects.

AGD has been linked to fertility in males, making BPA’s negative impact on the male reproductive system noteworthy. Men with an AGD lower than the median, which sits around 52 mm (2 in), have seven times the chance of being sub-fertile as compared to those with a longer AGD

Sparks Multiple Negative Brain Alterations

Further adding on to BPAs long list of negative effects, some research has also found that the chemical disrupts a gene responsible for proper nerve cell function, ultimately leading to compromised brain development. Researchers of the study, published in the journal Proceedings of the National Academy of Sciences, discovered that BPA could damage central nervous system development by disrupting a gene called Kcc2.

“Our study found that BPA may impair the development of the central nervous system, and raises the question as to whether exposure could predispose animals and humans to neurodevelopmental disorders,” study researcher Dr. Wolfgang Liedtke, M.D., Ph.D., said.

Another study found that exposure to bisphenol-A early in life can spark changes in gene expression. The changes occur in a part of the brain called the amygdala, which can lead to increased levels of anxiety.

The study abstract states:

“Early life exposure to Bisphenol A (BPA), a component of polycarbonate plastics and epoxy resins, alters sociosexual behavior in numerous species including humans. The present study focused on the ontogeny of these behavioral effects beginning in adolescence and assessed the underlying molecular changes in the amygdala.”

7. Obesity

Last, but certainly not least, BPA may be one of many factors responsible for the obesity epidemic. One study found that high BPA exposure is associated with obesity in the general adult population in the U.S.

Another study, examining BPA concentrations in the urine of kids aged 6 to 19, found that obese children made up 22% of individuals with the highest BPA levels in their urine. About 10% of kids who had the lowest BPA concentration in their urine were obese.

Additional Sources:

Forbes

NY Times

NationalGeographic

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