The National Cancer Institute’s page for Cannabis and Cannabinoids now lists several preclinical trials and studies in which the compounds have shown beneficial medical applications. While these merits come as no surprise for many, the real shocker here is Marijuana still being listed as a Schedule I substance in the eyes of the DEA.
The National Cancer Institute (NCI) is the United State’s primary agency in which cancer research and training is conducted. They are part of a larger umbrella of governmental agencies that comprise the Department of Health and Human Services (HHS). The NCI is largely responsible for the running the National Cancer Program, providing cancer-related information to the public, as well as developing programs and recommendations for the diagnosis, prevention, and treatment of cancer.
Now listed on the the NCI’s Cannabis and Cannabinoids page, which is assumed to be the United State’s official position regarding Marijuana’s potential application in treating cancer, are the following facts:
- Studies in mice and rats have shown that cannabinoids may inhibit tumor growth by causing cell death, blocking cell growth, and blocking the development of blood vessels needed by tumors to grow. Laboratory and animal studies have shown that cannabinoids may be able to kill cancer cells while protecting normal cells.
- A study in mice showed that cannabinoids may protect against inflammation of thecolon and may have potential in reducing the risk of colon cancer, and possibly in its treatment.
- A laboratory study of delta-9-THC in hepatocellular carcinoma (liver cancer) cells showed that it damaged or killed the cancer cells. The same study of delta-9-THC inmouse models of liver cancer showed that it had antitumor effects. Delta-9-THC has been shown to cause these effects by acting on molecules that may also be found innon-small cell lung cancer cells and breast cancer cells.
- A laboratory study of cannabidiol (CBD) in estrogen receptor positive and estrogen receptor negative breast cancer cells showed that it caused cancer cell death while having little effect on normal breast cells. Studies in mouse models of metastaticbreast cancer showed that cannabinoids may lessen the growth, number, and spread of tumors.
- A laboratory study of cannabidiol (CBD) in human glioma cells showed that when given along with chemotherapy, CBD may make chemotherapy more effective and increase cancer cell death without harming normal cells. Studies in mouse models of cancer showed that CBD together with delta-9-THC may make chemotherapy such astemozolomide more effective.
The page also discusses several other potential medical applications for Cannabis and Cannabinoids such as pain relief, appetite stimulation, as well as it being an effective treatment for nausea, anxiety, and depression.
The page concludes by stating the FDA has not approved Cannabis or any Cannabinoids for the treatment of cancer, but that two Cannabinoids (dronabinal and nabilone) are currently approved for the treatment of chemotherapy-related nausea and vomiting.
The NCI’s page on Cannabinoids and Cannabis as a treatment for cancer gives the impression that the currently schedule I substance, Marijuana, holds tremendous potential for medical applications.
“CANNABINOIDS MAY BE ABLE TO KILL CANCER CELLS WHILE PROTECTING NORMAL CELLS”