The body detoxifies what it can, when it can. As the adrenals heal and more energy becomes available, that metabolic function increases and copper along with other metals and toxins are released from sequestration. Depending on how well the liver can clear toxins there will be a period of months of increased symptoms due to detox. Caffeine enemas reduce these symptoms, and act like a form of dialysis through the gut wall, otherwise oxidative damage occurs until excess toxins and metals can be redistributed among the tissues until the liver can catch up.