I have tried quite large regular doses of ACV - though usually only about 4 - 6 tbsp a day (which is enough to cause loose BM for me). When I did a nine day juice fast I was taking about the amount you suggest and definitely had a lot of pain in the liver/gall bladder. But it hasn't made the flushes more effective as of yet. But it's such amazing brilliant stuff and I know it boosts all the body's organs so I keep taking it anyway!