Re: ATP Cofactors -- Ferventer was right!

Actually, niacin increases histamine levels...

"What happens is that it eventually depletes you body of histamine and the flush is greatly reduced. "

It's my understanding that niacin (any form) increases histamine release, and the release of other compounds from mast cells, but that doesn't mean they're released or dumped from the body.

Instead, since niacin is a methyl-acceptor, it blocks methylation (which helps degrade or break down histamine) and actually increases histamine levels in the body.

http://www.ncbi.nlm.nih.gov/pubmed/23426511

This can be a huge problem for those who develop Histamine Intolerance , as both methylation (and the DAO enzyme in the gut) need to function properly or histamine levels just increase and increase resulting in serious health consequences:

http://www.ncbi.nlm.nih.gov/pubmed/17490952

(Note that the full paper is available for free at the link, if you want to read more about the details).

Anyway, I'd be curious to know if anyone has benefited from using Iodine without the niacin/niacinamide/inositol hexanicotinate?

Thanks.