I tend to get this type of pain when I've had too much coffee (maybe drinking a couple of cups and doing a coffee enema the same day for a couple of days in a row). I've always assumed this meant my kidneys were overworked and knocking off the coffee helped. I would think 3 weeks straight is a bit long to take these meds without a break -- I'd stop for a week and then resume if you've been getting good results otherwise.