My issue with ARL supplements is the are not best quality: Vit A is palmitate which is supposed to be toxic, now good quality supplements use beta carotene. Also, the B12 probably is not methylcobalamin, which is the active form. The B vitamins are not in active form. No bioflavanoids with Vit c in some of the supplements, Paramin had no K2 etc. Also Vit E is not given as mixed tocopherols just d-alpha.