#4 reminds me of this, keep in mind that for years before the damage becomes apparent most Lyme infected feel invincible:
"To use conventional diagnostic tests such as the Western Blot, one has to think in paradoxes: the patient has to be treated with an effective treatment modality first before the patient recovers enough to produce the antibodies, which then are looked for in the test."
-- Dr. Klinghardt, Lyme Disease a Look beyond Antibiotics