Have you tried echinacea, my son has cold hands and feet which developed when I gave him lactobacillus gg probiotic, he is now being treated with trimethoprim to reduce the bacteria in him. My son has acid reflux and we have now switched to cimetidine to boost his immune system rather than using zantac. He is on lansoprazole and he can't cope with fats or oils like coconut oil which makes him produce to much acid bile so he may have a problem with his liver but blood tests done don't show anything up. He is on fluconazole. I am trying to get more fibre into his diet as I read this is good for sweeping toxins out of your system and keeping toxins from building up in the body, in your blood, in your organs.