Re: Chitin Synthesis Inhibitor.

Here is another study that shows that "lufenuron does not appear to possess antifungal properties."

http://www.ncbi.nlm.nih.gov/pubmed/16008236


Am J Vet Res. 2005 Jun;66(6):1090-3.
Comparison of susceptibility of fungal isolates to lufenuron and nikkomycin Z alone or in combination with itraconazole.
Hector RF, Davidson AP, Johnson SM.

Source
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.
Abstract

OBJECTIVE:
To evaluate and compare the in vitro antifungal properties of lufenuron and nikkomycin Z against isolates of Coccidioides immitis and Aspergillus fumigatus when used singly and in combination with the azole antifungal agent itraconazole.

SAMPLE POPULATION:
3 clinical isolates of A fumigatus and the Silveira strain of C immitis.

PROCEDURE:
The fungal isolates were tested in vitro for susceptibility to the single and combination of compounds by use of microtiter-format susceptibility methods. Minimum inhibitory concentration end points were determined visually, and the contents of representative wells were examined microscopically for evidence of morphologic effects on fungi.

RESULTS:
No evidence of inhibition, either by susceptibility testing or direct microscopic examination of treated cells, was obtained with lufenuron under experimental conditions. In contrast, nikkomycin Z, a known inhibitor of fungal chitin synthesis, had potent activity against C immitis when used singly. A synergistic interaction between nikkomycin Z and itraconazole was found against isolates of both species tested.

CONCLUSIONS AND CLINICAL RELEVANCE:
On the basis of our in vitro data, lufenuron does not appear to possess antifungal properties.