It will probably work with Chronic Fatigue Syndrome. I zapped a great deal in attempting to lessen hiv. The hiv viral load did not go down but I had way, way more energy. Supposedly blood electrification helps to unclump the red blood cells which enables them to produce more ATP besides stunning microbes. My personal experience is that I had way, way more energy. But I zapped 10 hours a day. Use it overnight when sleeping.