I use LDN for IBS and have headaches all the time. it doesn't seem to help my headaches though. maybe my body has just gotten used to it. I think I remember it helping with headaches in the beginning but I must have become too used to the drug. it doesn't have the same wonderful effects it did when I started it 4 months ago and I guess upping the dose , it would no longer be a LDN right? it would just be Naltrexone?